The Future Of Research Peptides: Several Different Peptides And Their Potential Medical applications

United States then they are called USA Peptides.  They can also be considered as small proteins. These small proteins characteristically function as signaling molecules in the human body, with over 7,000 naturally-occurring peptides identified to date. They bind to receptors on the cell surface, transmitting commands to other cells and molecules.

The application of specific peptides for treatment, otherwise called peptide therapy, has gained great popularity in recent years. This is attributed mostly to the fact that these peptides are highly definite (i.e., only do what you want them to do) while also being well-tolerated and safe. There were over 60 US FDA-approved peptide medications, 140 peptide drugs being evaluated in clinical trials, and 500 in pre-clinical development as of January 2015.

Once approved for medical use and human consumption these peptide drugs may come in the form of transdermal creams, nasal sprays, and oral tablets, although most are administered intradermally and by prescription only from a medical doctor.  For now, these research peptides are only sold for research purposes and not for human consumption. 

Would You Benefit from Peptide Therapy?

From immune modulation and tissue repair to fat loss and muscle building, peptide therapy comprises several different drugs with varied potential applications and effects. Some popular peptides are as follows.

Thymosin Beta 4 TB500

Discovered in high concentrations in wound tissue and certain blood cells involved in clotting, Thymosin Beta 4 (TB500), or Tβ4 is the predominant form of thymosin in our bodies. This signifies its vital role in the healing process. As a matter of fact, recent studies have shown that the first gene to be upregulated after an injury is the Tβ4 gene. As the body begins to recover, TB500 aids in the creation of new vessels in the injured area, which carry blood, nutrients, and reparative substances to the site. Thymosin Beta 4 also has anti-inflammatory properties, and works to decrease the amount of inflammatory substances, called cytokines. Inflammation plays a large role in many of the symptoms associated with a large number of conditions (i.e., Lyme disease, CFS, FM, autoimmune diseases, infections, etc.), making the potential impact of Thymosin Beta 4 TB500 is quite extensive.

Supplementing with TB500

The detection of the function of Tβ4 in the process of immune regulation has brought about its use as a valuable therapeutic agent. Various infections including HIV, AIDS, Influenza, and colds has been treated using Tβ4. Various inflammatory conditions have been managed by it as well, also in part-treatment following a heart attack due to its cardio and neuroprotective effects.

Treatment of patients suffering from Lyme disease or other infectious and/or inflammatory conditions using Tβ4 has recorded immense success. So far, Tβ4 has not proven to cause any side effects and is very well tolerated. It is a versatile and valuable drug that can be taken on its own or in combination with an existing therapy.

AOD 9064

AOD 9064 is an altered fragment of HGH which contains the piece of the molecule that is believed to be liable for HGH’s anti-obesity effects. The peptide has been proven to increase fat burning without the increase in blood sugar and growth rate as observed with HGH itself. AOD 9604 has been deemed safe for chronic use by the FDA, receiving Human GRAS status in 2014. In addition to its being used as an anti-obesity peptide, AOD 9604 has been shown to have very favorable cartilage repair and regenerative properties, especially when paired with peptide BPC 157.

Melanotan II (MT2)

Melanotan II (MT2) is an equivalent of alpha melanocyte stimulating hormone, responsible for pigmentation in skin and hair. This peptide has proven not only to increase skin pigmentation, resulting in a substantially tanner skin tone, but also to stimulate fat loss and increase libido. Its aphrodisiac effects were so significant that it was the basis for the development of another peptide, Bremelanotide PT 141, designed exclusively to address erectile and sexual dysfunction.

By increasing the melanin composition in skin, causing a darkening effect that simulates an excellent sun tan, a certain class of peptide drug has been used to help prevent skin cancer. Increased lean muscle mass and improved sex drive is also attributed to this peptide.

Bremelanotide PT 141

Aiming at its aphrodisiac effects Bremelanotide PT 141, or PT-141, was developed from Melanotan II, proven to have a significant effect on libido, producing sexual arousal in both men and women within minutes of administration. It has been shown to be effective in treating erectile dysfunction, even in men who have not responded to other ED treatments, such as Viagra. This peptide is also able to cross the blood-brain barrier, bypassing the vascular system and acting at the level of the central nervous system. This property gives Bremelanotide an advantage over traditional ED drugs, which can decrease blood pressure to dangerous levels. It can be administered as a nasal spray, making its use convenient and discreet.

Follistatin 344

These peptides are inhibitors of a protein called myostatin. Myostatin is secreted by muscle cells and acts to fundamentally block the development of new muscle fibers and, thus, the development of lean muscle mass. In fact, individuals who have mutations in the gene coding for this protein have significantly more muscle mass and enhanced strength. Follistatin344has been found especially useful in patients suffering from muscle-wasting diseases or who have difficulty gaining muscle, as its administration can generate enhanced muscle mass and strength.

SARMs S23, S4 & S22

SARMs such as the SARM S23 are selective androgen receptor modulators, which provide the benefits of anabolic steroids (i.e., increased muscle mass/strength, fat loss, increased bone density, increased libido) without the quantity and/or severity of unwanted effects. Androgens are naturally occurring hormones (such as testosterone) that regulate the development and maintenance of male sex physiognomies. SARMs are distinct from most oral steroids as they are not toxic to the liver.

PEG MGF

PEG MGF (Mechano growth factor) is a peptide derived from insulin-like growth factor-1 (IGF-1), which plays a broad role in childhood development with continued anabolic effects throughout adulthood. MGF has the ability to boost repair and growth of wasted tissue through the activation of muscle stem cells, thereby increasing the synthesis of proteins necessary for tissue growth. This is a perfect peptide for anyone suffering from muscle loss, either due to old age or a particular condition (i.e., HIV, cancer, etc.).